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Title 

GERI-BP002-A, novel inhibitor of Acyl-CoA : cholesterol acyltransferase produced by Aspergillus fumigatus F93

Authors 

Young Kook KimHyun Woo LeeKwang Hee SonByoung-Mog KwonTae Sook JeongDong-Heui LeeJongheon ShinYoungwan SeoSung Uk KimSong Hae Bok

Publisher 

Nature Publishing Group

Issue Date 

1996

Citation 

Journal of Antibiotics, vol. 49, no. 1, pp. 31-36

Keywords 

cholesterol acyltransferase inhibitorgeri bp002 aunclassified druganimal tissueantineoplastic activityaspergillus fumigatuscancer cell culturecarbon nuclear magnetic resonancecolumn chromatographydrug isolation

Abstract 

A new inhibitor of acyl-CoA : cholesterol acyltransfcrase (ACAT), designated GERI-BP002-A, was isolated from the culture broth of Aspergillus fumigalus F93 by acetone extraction, EtOAc extraction, SiO2 column chromatography and reverse phase HPLC. Spectroscopic analyses of the compound identified bis (2-hydroxy-3-tert-butyl-5-methylphenyl) methane as the structure and its molecular weight and formula to be 340 and C23H32O2, respectively. GERI-BP002-A inhibited ACAT activity by 50% at the concentration of 50 μM in an enzyme assay system using rat liver microsomes.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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