상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Solandelactones A-I, lactonized cyclopropyl oxylipins isolated from the hydroid Solanderia secunda

Authors 

Youngwan SeoKi Woong ChoJung-Rae RhoJongheon ShinByoung-Mog KwonSong Hae BokJun-Im Song

Publisher 

Elsevier

Issue Date 

1996

Citation 

Tetrahedron, vol. 52, no. 32, pp. 10583-10596

Keywords 

enzyme inhibitorfarnesyl trans transferasefatty acid derivativesolandelactoneunclassified druganimal tissuebiosynthesiscircular dichroismdrug isolationenzyme inhibition

Abstract 

Solandelactones A-I(1-9), cyclopropyl and lactone containing novel docosanoids have been isolated from the hydroid Solanderia secunda. The structure of these compounds have been elucidated by combined spectral and chemical studies. Configuration of the cyclopropyl ring has been essigned as the opposite of related oxylipins by NOESY experiments. Absolute stereochemistry has been determined on the basis of chemical transformations and CD measurements of synthetic derivatives. In addition, the biogenetic origin of solandelactones has been discussed. Solandelactones C, D and G exhibited moderate inhibitory activity against Farnesyl Protein Transferase.

ISSN 

0040-4020

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)