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Title 

Amplification of farnesyl protein transferase inhibitory activity from Aspergillus fumigatus F93 by Plackett-Burman design

Authors 

Kwang Hee SonYoung-Kook KimHyun Woo LeeWoo-Sang LeeSung Uk KimTae Sook JeongByoung-Mog KwonSong Hae Bok

Publisher 

Springer Verlag (Germany)

Issue Date 

1996

Citation 

Biotechnology Letters, vol. 18, no. 11, pp. 1297-1300

Keywords 

protein farnesyltransferaseaspergillus fumigatusenzyme activity

Abstract 

Fermentation optimization for the fungus Aspergillus fumigatus F93 was performed to amplify the most promising biological activity. Twelve active variables were analysed and optimized by the Plackett-Burman design, consisting of 16 experiments. Farnesyl protein transferase inhibitory activity showed the best response for the design, and selected parameters were confirmed by separate experiments in the optimized fermentation condition.

ISSN 

0141-5492

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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