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Title 

Metabolism of glycyrrhizin and baicalin by human intestinal bacteria

Authors 

Dong-Hyun KimIl-Sung JangHyeong Kyu LeeEun-Ah JungKyeu-Yup Lee

Publisher 

Pharmaceutical Society of Korea

Issue Date 

1996

Citation 

Archives of Pharmacal Research, vol. 19, no. 4, pp. 292-296

Keywords 

bacteroides J-37baicalinglycyrrhizinintestinal bacteria

Abstract 

By human intestinal bacteria, glycyrrhizin (18β-glycyrrhetic acid β-D-glucuronyl α-D-glucuronic acid, GL) and baicalin (baicalein β-D-glucuronic acid) were metabolized to glycyrrhetinic acid and baicalin, respectively. However, α-glucuronidase of Bacteroides JY-6 isolated from human intestinal bacteria hydrolyzed GL or 18β-glycyrrhetinic acid α-D-glucuronic acid to 18β-glycyrrhetic acid but did not baicalin. However, E coli β-glucuronidase from human intestinal bacteria hydrolyzed baicalin to baicalein, but did not GL. β-Glucuronidase of mammalian tissues hydrolyzed both GL and baicalin.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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