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Title 

Cytotoxicity of trichothecenes to human solid tumor cells In vitro

Authors 

Sang Un ChoiEun Jung ChoiKwang Hee KimNam Young KimByoung-Mog KwonSung Uk KimSong Hae BokSo Young LeeChong Ock Lee

Publisher 

Pharmaceutical Society of Korea

Issue Date 

1996

Citation 

Archives of Pharmacal Research, vol. 19, no. 1, pp. 6-11

Keywords 

cytotoxicitygliocladiumhuman tumor cell linetrichothecenestrichotheciumcisplatindoxorubicinantineoplastic activity

Abstract 

The trichothecenes are sesquiterpenoid mycotoxins characterized by the 12,13-epoxytrichothec-9-ene ring system. We have tested cytotoxicity of several naturally-occurring or synthesized trichothecenes against human solid tumor cell lines. Among them, trichothecin (I) and 4-β-Acetoxy-12,13-epoxytrichothec-9-ene (trichodermin, II) exhibited highly cytotoxic activities. 4-β-Hydroxy-12,13-epoxytrichothec-9-ene (trichodermol, III) and 4-β-Methoxy-12,13-epoxytrichothec-9-ene (IV) had mild cytotoxicities. But 12,13-Epoxytrichothec-9-ene-4-one (V) and 4-α-Hydroxy-12,13-epoxytrichothec-9-ene(VI) had no cytotoxicities up to 10 μg/ml. And in the tested cell lines, HCT15 colon cancer cell line was the most sensitive to all tested trichothecenes.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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