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Title 

Isolation and characterization of antifungal compound produced by Aspergillus candidus F1484

 

Aspergillus candidus F1484 균주가 생산하는 항진균 화합물의 분리 및 특성

Authors 

Sung Uk KimSo Young LeeSung Kyu KimKwang Hee SonYoung Kook KimS S MoonSong Hae Bok

Publisher 

Korean Journal of Applied Microbiology and Biotechnology

Issue Date 

1996

Citation 

Korean Journal of Applied Microbiology & Biotechnology, vol. 24, no. 5, pp. 574-578

Keywords 

antifungal activityC. albicanscytotoxicitydimorphism

Abstract 

In the course of screening for the antifungal compounds against Candida albicans, an antifungal compound (F1480) was isolated from the culture broth of Aspergillus candidus F1484. Isolation and purification of compound F1484 were performed using ethyl acetate extraction, silica gel column chromatography, ODS column chromatography, and preparative HPLC. The structure of compound F1484 was determined by the spectroscopic analyses of EI-MS, 13C-, 1H-NMR, DEPT, HMQC, and HMBC. This compound appeared to have a structure of antifungal agent, chloroflavonin. In addition to antifungal activities against the yeast phase of Candida species, compound F1484 showed cytotoxic effect against various human tumor cell lines.

ISSN 

0257-2389

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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