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Title 

Effect of soybean oil on the enhanced expression of hirudin gene in Hansenula polymorpha

Authors 

Chul Ho KimJung Hoon SohnEui Sung ChoiSang Ki Rhee

Publisher 

Springer Verlag (Germany)

Issue Date 

1996

Citation 

Biotechnology Letters, vol. 18, no. 4, pp. 417-422

Keywords 

hirudinsoybean oilgene expressionhansenula polymorpha

Abstract 

A heterologous gene from bloodsucking leech for anticoagulant, hirudin, has been expressed in the methylotrophic yeast Hansenula polymorpha. The addition of 1% (v/v) soybean oil to the medium as a stabilizer enhanced the expression of the hirudin gene in H. polymorpha with MOX promoter. The production of hirudin in the medium with soybean oil was 320 mg/L in a 5 L fermenter.

ISSN 

0141-5492

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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