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Title 

Production of D-β-hydroxyisobutyric acid from isobutyric acid by Candida rugosa

Authors 

In Young LeeWon Kyoung HongYoung Bo HwangChul Ho KimEui Sung ChoiSang Ki RheeYoung Hoon Park

Issue Date 

1996

Citation 

Journal of Fermentation and Bioengineering, vol. 81, no. 1, pp. 79-82

Keywords 

candida rugosaD-β-hydroxyisobutyric acidproductionisobutyric acidisobutyric acid derivativecandidacontrolled studyfatty acid synthesis

Abstract 

Production of D-β-hydroxyisobutyric acid (D-HIBA) from isobutyric acid (IBA) was investigated using Candida rugosa IFO 0750. Cell growth and D-HIBA production decreased as the substrate concentration increased. A considerable degradation of D-HIBA was observed when the substrate, IBA, was depleted in the medium. Specific production rate of D-HIBA increased as glucose concentration decreased, while the conversion yield of IBA to D-HIBA showed an opposite trend. With a controlled feeding of IBA and glucose, a high titer of D-HIBA (100 g/l) could be obtained by a fed-batch cultivation of Candida rugosa.

ISSN 

0385-6380

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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