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Title 

Metabolites and amino acids affecting cellular cofactor concentrations and poly-β-hydroxybutyrate biosynthesis in Alcaligenes eutrophus

Authors 

Mi Kyung KimIn Young LeeYoung Hoon Park

Publisher 

Springer Verlag (Germany)

Issue Date 

1996

Citation 

Biotechnology Letters, vol. 18, no. 5, pp. 559-564

Keywords 

amino acidpoly(3 hydroxybutyric acid)pyruvic acidbiosynthesismetabolite

Abstract 

Additon of pyruvate or leucine was found to be efficient for increasing the intracellular ratios of NADH/NAD and NADPH/NADP while reducing the coenzyme A concentration during the cultivation of Alcaligenes eutrophus. Poly- β -hydroxybutyrate (PHB) accumulation was enhanced more than 2-fold since metabolic flux of acetyl-CoA into PHB synthetic pathway could be facilitated by the changes of the cofactor concentrations.

ISSN 

0141-5492

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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