상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Decursin : a cytotoxic agent and protein kinase C activator from the root of Angelica gigas

Authors 

Kyung Seop AhnWoong-Seop SimIk Hwan Kim

Publisher 

Georg Thieme Verlag

Issue Date 

1996

Citation 

Planta Medica, vol. 62, no. 1, pp. 7-9

Keywords 

angelica gigas Nakaicytotoxic activitydecursinprotein kinase C activationumbelliferaeangelica gigans extractcytotoxic agentphorbol dibutyrateplant extract

Abstract 

A cytotoxic compound was purified from the root of Angelica gigas Nakai by silica gel chromatography and preparative HPLC. As a result of the structure analysis by mass, IR, 1H-NMR, and 13C-NMR spectrometry, the effective compound was identified as decursin, a pyranocoumarin characterized originally from Angelica decursiva Fr. et Sav. In vitro cytotoxicity testing showed that decursin displayed toxic activity against various human cancer cell lines, for which the ED50 of decursin was about 5-16 μg/ml. On the other hand, decursin displayed relatively low cytotoxicity against normal fibroblasts. Decursin also activated protein kinase C (PKC) in vitro, which indicates that the cytotoxic activity of decursin may be related to the protein kinase C activation.

ISSN 

0032-0943

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)