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Title 

Selective suppression of In vitro T-dependent humoral immunity by synthetic food additive antioxidants

Authors 

Hwan Mook KimSang Bae HanWoo Ick ChangByung Hwa HyunGoo Taeg OhChang Joon AhnYoung Nam Cha

Publisher 

Japanese Society of Toxicoogical Sciences / The Japanese Society of Toxicology

Issue Date 

1996

Citation 

Journal of Toxicological Sciences, vol. 21, no. 0, pp. 41-45

Keywords 

BHTDMSOPGPrimary antibody responsesantioxidantbutylcresoldimethyl sulfoxidefood additivegallic acid propyl esterantibody response

Abstract 

Effect of antioxidants on humoral immune responses, such as butylated hydroxytoluene (BHT), n-propyl gallate (PG) and dimethyl sulfoxide (DMSO) is suppression in in vitro antibody production. These antioxidants all inhibited T-dependent B cell response, not T-independent and polyclonal B cell response. These data suggest that antioxidants suppress humoral immunity by suppression of regulation of T cells or action of macrophages on B cells, not by direct suppression of B cells. The other possible explanation for antioxidant action is the lack of T-b cell contact required for the triggering of the B cell response with T-dependent antigens.

ISSN 

0388-1350

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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