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Title 

Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus

Authors 

Hwan Mook KimSang Bae HanGoo Taeg OhYoung Hee KimDong Ho HongNam Doo HongIck Dong Yoo

Publisher 

Elsevier

Issue Date 

1996

Citation 

International Journal of Immunopharmacology, vol. 18, no. 5, pp. 295-303

Keywords 

Cell mediated immunityHumoral immunityPhellinus linteusPolysaccharidepolysaccharideanimal cellcellular immunityhumoral immunitymushroomspleen cell

Abstract 

Polysaccharide was purified from mycelial culture of Phellinus linteus (PL) and its effect on immunocompetence of normal splenocytes was observed. Overall in vitro and in vivo immune function was enhanced by addition of PL into culture of mouse spleen lymphocyte and I.p. injection into mouse, while β-glucans and other polysaccharides only raised the level of T lymphocyte-mediated immunity. PL stimulated immune functions of T lymphocytes, such as proliferation of T lymphocyte induced by mixed lymphocyte reaction and cytotoxicity of cytotoxic T cells responding to alloantigen. Nonspecific immune functions mediated by natural killer cells and macrophages were increased by treatment of PL in vitro and in vitro. PL also stimulated humoral immune function positively, such as T-dependent and T-independent primary antibody responses, and acted as a polyclonal activator on B cell. PL exhibited a wider range of immunostimulation and antitumor activity than other polysaccharides isolated from Basidiomycetes.

ISSN 

0192-0561

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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