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Title 

Antifungal activities of peptides with the sequence 10-17 of magainin 2 at the N-termini against Aspergillus fumigatus

Authors 

Myung Kyu LeeDong Gun LeeSong Yub ShinSung Gu LeeJoo Hyun KangKyung Soo Hahm

Publisher 

Microbiological Society of Korea

Issue Date 

1996

Citation 

Journal of Microbiology, vol. 34, no. 3, pp. 274-278

Keywords 

Antifungal activityAspergillus fumigatusGlucan synthaseMagainin 2 derived peptideSynthetic peptide

Abstract 

Two peptides, MA-inv and MA-ME, with the sequence 10-17 of magainin 2 at their N-termini were designed and synthesized. The peptides had higher antifungal activities against Aspergillus fumigatus without hemolytic activities. The minimal inhibition concentratory (MIC) values of both peptides against A. fumigatus were 5 μg/ml, whereas those of the native peptides, magainin 2 and melittin, were 10 μg/ml. At 3 μg/ml, MA-inv and MA-ME inhibited the mycelium growth of A. fumigatus by 94.6% and 97.3%, respectively, whereas magainin 2 and melittin inhibited by 62.2% and 32.4%, respectively. MA-inv showed up to 80% inhibition of (1,3)-β-D-glucan synthase activity of A. fumigatus. The peptides also showed antifungal activities for other fungi of Aspergillus sp. However, the antibiotic activities of MA-ME against Escherichia coli, Bacillus subtilis and Fusarium oxysporum were more effective than those of MA-inv, suggesting that the C-terminal sequences of MA-inv and MA-ME may also influence their antibiotic activities. These results suggest that the N-terminal sequence of the designed peptides, KKFGKAFV, is important for their antifungal activities against A. fumigatus and their C-terminal sequences are related to the organism selectivity.

ISSN 

1225-8873

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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