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Title 

Antifungal effect of melittin-hybrid synthetic peptides for Fusarium oxysporum

 

Melittin-hybrid 합성 펩타이드가 Fusarium oxysporum의 성장에 미치는 저해효과

Authors 

Dong Gun LeeSong Yub ShinSung Gu LeeMyung Kyu LeeKyung Soo Hahm

Publisher 

Korean Journal of Applied Microbiology and Biotechnology

Issue Date 

1996

Citation 

Korean Journal of Applied Microbiology & Biotechnology, vol. 24, no. 5, pp. 529-533

Keywords 

β-1.3 glucan synthaseAntifungal activityHybrid peptideMelittin

Abstract 

Melittin (ME) from honey-bee venom has a broad range of strong antimicrobial activity, but it has hemolytic activity against eukaryotic cells. In order to design peptides with powerful antifungal activity without cytotoxic property of ME and understand structure-antifungal activity relationships, the hybrid peptides derived from the sequences of ME and cecropin A (CA) or magainin 2 (MA), MA(10-17)ME(1-12) and CA(1-8)ME(1-12), were synthesized by solid phase method. MA(10-17)ME(1-12) showed potent antifungal activity comparable to ME against Fusarium oxysporum with no hemolytic activity against human red blood cells. The hybrid peptides showed strong inhibition of (1,3)-β-D-glucan synthase. This result indicates that the antifungal activity of the hybrid peptides against Fusarium oxysporum is attributed to the inhibition of cell wall synthesis. The results therefore showed a successful design of a peptide having antifungal activity without hemolytic property.

ISSN 

0257-2389

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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