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Title 

A specific association of ERK3 with B-raf in rat hippocampus

Authors 

Seung Ho KimYun Chung Yang

Publisher 

Elsevier

Issue Date 

1996

Citation 

Biochemical and Biophysical Research Communications, vol. 229, no. 0, pp. 577-581

Keywords 

adenosine triphosphatemitogen activated protein kinasephosphotransferaseraf proteinanimal tissueanion exchange chromatographycell fractionationcell lysateenzyme mechanismimmunoprecipitation

Abstract 

The possible formation of a stable complex between extracellular signal-regulated kinases (ERKs) and Raf protein kinases was investigated in an attempt to understand the molecular mechanism by which Raf protein kinases were differentially regulated in response to the various stimuli, leading to the activation of ERKs in rat hippocampus. ERK3 was found to coelute with B-Raf, but not c-Raf1, after fractionation of rat hippocampal lysates by QMA anionic exchange chromatography. ERK3 was released into soluble supernatant fraction from the B-Raf, but not c-Raf1, immunoprecipitate, after incubation with ATP. These results, taken together, suggest the specific association of ERK3 with B-Raf in rat hippocampus.

ISSN 

0006-291X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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