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Title 

Role of HLA class II alleles in Korean patients with IDDM

Authors 

H C LeeH IkegamiT FugisanaT OgiharaS W ParkY S ChungJ O ParkE J LeeS K LimK R KimK B HuhYong Sung KimDae Sil LeeD H Kim

Publisher 

Elsevier

Issue Date 

1996

Citation 

Diabetes Research and Clinical Practice, vol. 31, no. 0, pp. 9-15

Keywords 

HLAHuman leukocyte antigenIDDMInsulin-dependent diabetes mellitusPCRPolymerase chain reactionHLA antigen class 2alleleAllelesGenes, MHC Class II

Abstract 

MHC associations with IDDM in the Korean population were studied to investigate genetic susceptibility to this disorder. The frequencies of HLA-DR3, -DR4 and -DR9 were significantly higher in diabetic patients. However, the frequency of DR2 was significantly decreased in diabetic patients. DQA1*0301 and DQA1*0501 were positively and DQA1*0102 and DQA1*0201 negatively associated with IDDM. DQB1*0301 and DQB1*0601 were negatively associated with IDDM. Heterodimers DQA1*0301-DQB1*0201, DQA1*0501-DQB1*0201 and DQA1*0501-DQB1*0302 were positively associated and DQA1*0102-DQB1*0601 negatively associated with IDDM. The frequencies of DR3-DQB1*0301-DQB1*0201 and -DQA1*0501-DQB1*0201 were significantly higher in diabetic patients. The frequencies of DR4-DQA1*0301 DQB1*0201 and DR9-DQA1*0301-DQB1*0303 were significantly higher in diabetic patients. The presence of non-aspartic acid at position 57 of the DQβ-chain was not associated with susceptibility to IDDM. However, the frequency of Arg 52 homozygotes was significantly higher in diabetic patients. These results suggest a role of the MHC molecule and also suggest racial differences in susceptibility to IDDM even within the Asian populations.

ISSN 

0168-8227

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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