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Title 

Benzastatins E, F, and G : new indoline alkaloids with neuronal cell protecting activity from Streptomyces nitrosporeus

Authors 

Won Gon KimJong Pyung KimH KoshinoK Shin-YaH SetoIck Dong Yoo

Publisher 

Elsevier

Issue Date 

1997

Citation 

Tetrahedron, vol. 53, no. 12, pp. 4309-4316

Keywords 

alpha tocopherolglutamic acididebenoneindole alkaloidneuroprotective agentanimal cellanimal tissuecell linecontrolled studydrug isolation

Abstract 

Three new indoline alkaloids, benzastatins E (5), F (6), and G (7), were isolated from the culture broth of Streptomyces nitrosporeus 30643 as neuronal cell protecting substances. Their structures were elucidated on the basis of spectral data, 5, 6, and 7 suppressed glutamate toxicity in N18-RE-105 cells with EC50 values of 1.7, 3.6, and 12.2 μM, respectively.

ISSN 

0040-4020

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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