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Title 

New diphenazines with neuronal cell protecting activity, phenazostatins A and B, produced by Streptomyces sp.

Authors 

Won Gon KimIn Ja RyooBong Sik YunK Shin-YaH SetoIck Dong Yoo

Publisher 

Nature Publishing Group

Issue Date 

1997

Citation 

Journal of Antibiotics, vol. 50, no. 9, pp. 715-721

Keywords 

glutamic acidneuroprotective agentphenazine derivativephenazostatin aphenazostatin bscavengerunclassified druganimal celldrug isolationfermentation

Abstract 

Phenazostatins A and B, new diphenazine compounds, were isolated from the culture broth of Streptomyces sp. 833 as new neuronal cell protecting substances which also showed free radical scavenging activity. In the cell assay, phenazostatins A and B inhibited glutamate toxicity in N18-RE-105 cells with EC50 values of 0.34 and 0.33 μM, respectively.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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