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Title 

The retinoblastoma gene product regulates Sp1-mediated transcription

Authors 

Seong-Jin KimU S OnwutaYoung Ik LeeR LiM R BotchanP D Robbins

Publisher 

American Society for Microbiology

Issue Date 

1992

Citation 

Molecular and Cellular Biology, vol. 12, no. 6, pp. 2455-2463

Keywords 

gene producttranscription factorgene expression regulationoncogene c fosoncogene c mycretinoblastomatranscription initiationtranscription regulationGene Expression RegulationPromoter Regions (Genetics)

Abstract 

We have demonstrated that the retinoblastoma gene product (Rb) can positively regulate transcription from the fourth promoter of the insulinlike growth factor II gene. Two copies of a motif (the retinoblastoma control element) similar to that found in the human c-fos, transforming growth factor β1, and c-myc promoters are responsible for conferring Rb regulation to the fourth promoter of the insulinlike growth factor II gene. We have shown that the transcription factor Sp1 can bind to and stimulate transcription from the retinoblastoma control element motif. Moreover, by using a GAL4-Sp1 fusion protein, we have directly demonstrated that Rb positively regulates Sp1 transcriptional activity in vivo. These results indicate that Rb can function as a positive regulator of transcription and that Sp1 is one potential target, either directly or indirectly, for transcriptional regulation by Rb.

ISSN 

0270-7306

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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