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Title 

Genomic aberrations in human hepatoblastomas detected by 2-dimensional gel analysis

Authors 

Hisaki NagaiHiroaki TsumuraMathurose PonglikitmongkolYong Sung KimKenichi Matsubara

Publisher 

American Association for Cancer Research

Issue Date 

1995

Citation 

Cancer Research, vol. 55, no. 20, pp. 4549-4551

Keywords 

humanhuman tissuetwo dimensional gel electrophoresisElectrophoresis, Gel, Two-DimensionalHuman

Abstract 

Hepatoblastoma is a frequent embryonic tumor found in children. The mechanism of its formation and development remain unknown. We analyzed genomic DNA aberrations associated with three hepatoblastomas by means of restriction landmark genomic scanning (I. Hatada et al., Proc. Natl. Acad. Sci. USA, 88:9523-9527, 1991). About 2000 Not1 restriction landmarks were monitored in each of the hepatoblastomas, which revealed that the intensity of eight spots decreased in the tumor genome, suggesting allelic loss. Three of these spots were identical to those that decreased in human hepatocellular carcinomas. These results suggested that common, early events are involved in the genesis of the two types of liver tumor.

ISSN 

0008-5472

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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