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Title 

Transforming growth factor-β1 inhibits human keratinocyte proliferation by upregulation of a receptor-type tyrosine phosphatase R-PTP-κ gene expression

Authors 

Young YangMin Chan GilSi Myung ByunIn Pyo ChoiKwang Ho PyunHyunjung Ha

Publisher 

Elsevier

Issue Date 

1996

Citation 

Biochemical and Biophysical Research Communications, vol. 228, no. 0, pp. 807-812

Keywords 

messenger rnaprotein tyrosine phosphatasereceptor proteintransforming growth factor beta1vanadate sodiumcell proliferationcontrolled studygene inductionhumanhuman cell

Abstract 

We studied regulation of a receptor-type tyrosine phosphatase R-PTP-(κ) gene expression in a human keratinocyte cell line, HaCaT. Addition of TGF-B1 to the HaCaT cells markedly induced the expression of R-PTP-(κ) mRNA in a time- and dose-dependent manner. The induction of R-PTP-(κ) mRNA expression was observed at a dose as low as 0.02 ng/ml TGF-B1 and reached a peak at 2 ng/ml TGF-B1 after 6 h treatment. The TGF-B1-induced R-PTP-(κ) mRNA expression was suppressed by sodium orthovanadate, a tyrosine phosphatase inhibitor, and H7, a serine/threonine kinase inhibitor, but not by genistein, a tyrosine kinase inhibitor, In addition, the inducing effect is not dependent on de novo protein synthesis. Taken together, these results suggest that TGF-β1 inhibits the human keratinocyte proliferation in vitro, possibly through induction of R-PTP-(κ)K gene expression.

ISSN 

0006-291X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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