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Title 

Anti-inflammatory effects of Stephania tetrandra S. moore on interleukin-6 production and experimental inflammatory disease models

Authors 

Hyung Sik KangYoung Ho KimC S LeeJung Joon LeeIn Pyo ChoiKwang Ho Pyun

Publisher 

Taylor & Francis

Issue Date 

1996

Citation 

Mediators of Inflammation, vol. 5, no. 0, pp. 280-291

Keywords 

anti-fibrosisanti-inflammationIL-6 productionStephania tetrandrainterleukin 6superoxideantiinflammatory activityChinese herbcontrolled studyfibroblast

Abstract 

Deregulation of interleukin-6 (IL-6) expression caused the synthesis and release of many inflammatory mediators. It is involved in chronic inflammation, autoimmune diseases, and malignancy. Stephania tetrandra S. Moore is a Chinese medicinal herb which has been used traditionally as a remedy for neuralgia and arthritis in China. To investigate the anti-inflammatory effects of S. tetrandra S. Moore in vitro and in vivo, its effects on the production of IL-6 and inflammatory mediators were analysed. When human monocytes/macrophages stimulated with silica were treated with 0.1-10 μg/ml S. tetranda S. Moore, the production of IL-6 was inhibited up to 50%. At these concentrations, it had no cytotoxicity effect on these cells. It also suppressed the production of IL-6 by alveolar macrophages stimulated with silica. In addition, it inhibited the release of superoxide anion and hydrogen peroxide from human monocytes/macrophages. To assess the anti-fibrosis effects of S. tetrandra S. Moore, its effects on in vivo experimental inflammatory models were evaluated. In the experimental silicosis model, IL-6 activities in the sera and in the culture supernatants of pulmonary fibroblasts were also inhibited by it. In vitro and in vivo treatment of S. tetrandra S. Moore reduced collagen production by rat lung fibroblasts and lung tissue. Also, S. tetrandra S. Moore reduced the levels of serum GOT and GPT in the rat cirrhosis model induced by CCl4, and it was effective in reducing hepatic fibrosis and nodular formation. Taken together, these data indicate that it has a potent anti-inflammatory and antifibrosis effect by reducing IL-6 production.

ISSN 

0962-9351

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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