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Title 

Inhibition of phospholipase Cγ1 by the prenylated flavonoids from Sophora flavescens

Authors 

Hyun Sun LeeHack Ryong KoShi Yong RyuWon Keun OhBo Yeon KimSoon Cheol AhnTae Ick MheenJong Seog Ahn

Publisher 

Georg Thieme Verlag

Issue Date 

1997

Citation 

Planta Medica, vol. 63, no. 3, pp. 266-268

Keywords 

flavonoidphospholipase csophora flavescens extractenzyme inhibitionFlavonoidsPhospholipase CPhospholipase C gammaSophora flavescens

Abstract 

The effect on the phospholipase Cγ1 activity of eleven prenylated flavonoids from Sophorn flavescens was investigated. These flavonoids exhibited relatively strong inhibitory activity with IC50 values ranged from 7.5 x 10-6M to 35 x 10-6 M with the exception of kushenol H (4) (IC50 value; > 5.3 x 10-4M). The presence of C3-OH resulted in a significant diminution of activity and the configuration of C3-OH is likely to be another factor influencing the activity. In addition, hydration of the C-4'''-C-5''' double bond of the lavandulyl side chain caused complete loss of activity. These data suggest that the presence and configuration of C3-OH are related to the inhibitory activity and the lavandulyl side chain is also important for high inhibitory activity against PLCγ1.

ISSN 

0032-0943

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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