상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Topical anti-inflammatory activity of dianemycin isolated from Streptomyces sp. MT 2705-4

Authors 

Song Jin LeeHyun Pyo KimByoung Keun ParkSoon Cheol AhnHyun Sun LeeJong Seog Ahn

Publisher 

Pharmaceutical Society of Korea

Issue Date 

1997

Citation 

Archives of Pharmacal Research, vol. 20, no. 4, pp. 372-374

Keywords 

Anti-inflammatory activityDelayed hypersensitivityDianemycinEar edemaStreptomycesTopicalUV-erythema

Abstract 

In order to develop new anti-inflammatory agents having different action mechanisms compared with nonsteroidal and steroidal anti-inflammatory drugs, the culture broths of various actinomycetes isolated from soil were screened using an in vivo mouse ear edma assay and one strain (Streptomyces sp. MT 2705-4: KCTC 8651P) was selected. Activity-guided purification led to the isolation of a polyether compound, dianemycin. Topically, dianemycin showed a potent anti-inflammatory activity in mouse ear edema induced by croton-oil or arachidonic acid. ED50 value of dianemycin was found to be 0.8 mg/ear compared to 0.4 mg/ear of prednisolone in croton-oil ear edema. However, dianemycin did not show the inhibitory activity in UV-erythema and delayed hypersensitivity reaction. These results indicate that dianemycin is a potential topical anti-inflammatory agent.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)