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Title 

Acyl-CoA : cholesterol acyltransferase inhibitors from Magnolia obovata

Authors 

Byoung-Mog KwonMi Kyung KimSeung Ho LeeJeong-Ah KimIhn-Rhan LeeYoung Kook KimSong Hae Bok

Publisher 

Georg Thieme Verlag

Issue Date 

1997

Citation 

Planta Medica, vol. 63, no. 6, pp. 550-551

Keywords 

cholesterol acyltransferase inhibitorcholesterol metabolismhypercholesterolemiaenzyme inhibitorssterol O-acyltransferaseMagnolia heptapetala

Abstract 

In the course of a search for acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors from natural sources, new types of ACAT inhibitors were isolated from the extract of Magnolia obovata leaves, and identified as obovatol, honokiol, and magnolol. The active compounds inhibit rat liver ACAT with IC50 values of 42, 71, and 86 μM, respectively.

ISSN 

0032-0943

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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