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Title 

Polyacetylene analogs, isolated from hairy roots of Panax ginseng, inhibit Acyl-CoA : cholesterol acyltransferase

Authors 

Byoung-Mog KwonSook-Hee RoMi Kyung KimJi Youn NamHyun-Ju JungIhn-Rhan LeeYoung Kook KimSong Hae Bok

Publisher 

Georg Thieme Verlag

Issue Date 

1997

Citation 

Planta Medica, vol. 63, no. 6, pp. 552-553

Keywords 

cholesterol acyltransferase inhibitorpanaxydiolpanaxydolpanaxynolpanaxytriolpolyacetylene derivativeenzyme inhibitionginsengplant rootenzyme inhibitors

Abstract 

In the course of our screening program for acylCoA:cholesterol acyltransferase (ACAT) inhibitors from Korean herbal medicines, ACAT inhibitors were isolated from the hairy roots of Panax ginseng (Araliaceae) and identified as panaxynol, panaxydol, panaxydiol, and panaxytriol. These active compounds inhibit rat liver ACAT with IC50 values of 94, 80, 45 and 79 μM, respectively.

ISSN 

0032-0943

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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