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Title 

Polymorphic sequence of Korean native goat lactoferrin exhibiting greater antibacterial activity

Authors 

Tae Hoon LeeK ShimazakiS L YuMyung Soo NamSun Jung KimKyung Kwang LeeDae Yeul Yu

Publisher 

Wiley-Blackwell

Issue Date 

1997

Citation 

Animal Genetics, vol. 28, no. 0, pp. 367-369

Keywords 

antibacterial activityKorean Native goatlactoferrin polymorphism

Abstract 

Lactoferrin, which exhibits antibacterial activity to protect infants from infectious disease, is a major component of colostrum and milk. Lactoferrin was purified from the colostrum of Korean Native goat, and the cDNA from the mammary gland mRNA of the animal was cloned and sequenced. The nucleotide sequence of the lactoferrin gene of Korean Native goat was found to differ in 15 sites from that of the goat lactoferrin gene reported earlier. This difference in nucleotide sequence resulted in six amino acid substitutions: five in the N-lobe and one in the C-lobe. The antibacterial activity of Korean Native goat lactoferrin was found to be greater than that of Sannen goat lactoferrin.

ISSN 

0268-9146

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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