상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

MR566A and MR566B, new melanin synthesis inhibitors produced by Trichoderma harzianum I. : taxonomy, fermentation, isolation and biological activities

Authors 

Choong Hwan LeeMyung Chul ChungHo Jae LeeKyung Sook BaeYung Hee Kho

Publisher 

Nature Publishing Group

Issue Date 

1997

Citation 

Journal of Antibiotics, vol. 50, no. 6, pp. 469-473

Keywords 

cyclopentane derivativeisocyanic acid derivativemelanin synthesis inhibitoroxazole derivativeunclassified druganimal cellbiosynthesisdrug isolationdrug purificationdrug synthesis

Abstract 

New melanin synthesis inhibitors (MR566A and B) and six related known isocyanocyclopentenes were isolated from the fermentation broth of Trichoderma harzianum. The IC50 values of MR566A and B against mushroom tyrosinase were 1.72 and 47 μM, respectively. They inhibited melanin biosynthesis in B16 melanoma cells with MIC values of 0.1 and 2.2 μM, respectively. Also isolated from the same culture extract of T. harzianum was a new oxazole (MR93B), which showed no inhibitory activity against mushroom tyrosinase at a concentration of 1,000 μg/ml.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)