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Title 

Biosynthesis of peptide inhibitor MR-387 by Streptomyces neyagawaensis

Authors 

Myung Chul ChungChoong Hwan LeeHo Jae LeeYung Hee KhoHyo Kon Chun

Publisher 

Springer Verlag (Germany)

Issue Date 

1997

Citation 

Biotechnology Letters, vol. 19, no. 7, pp. 607-610

Keywords 

peptide synthaseprotein inhibitorbiosynthesisStreptomycesStreptomyces neyagawaensis

Abstract 

Biosynthesis of MR-387 by Streptomyces neyagawaensis SL-387 was studied by testing the incorporation of radioactive precursors and the detection of biosynthetic enzyme. L-Phenylalanine, L-valine, L-proline, and acetic acid were efficiently incorporated into MR-387, but phenylethylamine and oxalic acid were not. These results suggest that the (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid moiety of MR-387 is synthesized from phenylalanine and acetic acid but not directly via the phenylethylamine. Synthesis of MR-387 is mediated by a peptide synthetase with a novel activity.

ISSN 

0141-5492

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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