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Title 

Synergistic stimulation of fibrinogen gelation by casein kinase II and polycationic compounds

Authors 

Kyoungho SukJin Young LeeSeung Ho Kim

Publisher 

International Union of Biochemistry and Molecular Biology

Issue Date 

1997

Citation 

Biochemistry and Molecular Biology International, vol. 42, no. 3, pp. 487-495

Keywords 

casein kinase IIpolycationic compoundfibrinogenhemostasis

Abstract 

The processes of thrombin-induced gelation of the fibrinogen may be influenced by a variety of factors including phosphorylational state of the fibrinogen. Casein kinase II (CKII) has been shown to phosphorylate fibrinogen in vitro and accelerate gelation of the fibrinogen. In this work, we have demonstrated that CKII and polycationic compounds such as polylysine, spermine, and spermidine synergistically stimulate thrombin-induced gelation of the fibrinogen. These polycationic compounds were also found to increase the stimulatory effects of CKII on the platelet aggregation. Current findings suggest potential role of CKII and polycationic compounds in the process of hemostasis.

ISSN 

1039-9712

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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