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Title 

Antifungal activities of magainin-2 hybrid peptides against Trichosporon beigelii

Authors 

Dong Gun LeeSong Yub ShinSung Gu LeeKil Lyong KimMyung Kyu LeeKyung Soo Hahm

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

1997

Citation 

Journal of Microbiology and Biotechnology, vol. 7, no. 1, pp. 49-51

Keywords 

Antifungal activityHybrid synthetic peptidesMagainin-2Trichosporon beigelit

Abstract 

In order to obtain a synthetic peptide with a more potent antifungal activity than magainin-2 but without hemolytic activity, four hybrid peptides were designed from the sequences of magainin 2 and cecropin A and their antifungal activities against Trichosporon beigelii were investigated. The result showed that analogue 2 and 4 exhibited better antifungal activity against T. beigelii than magainin-2 but no hemolytic activities. The peptides, therefore, could be used as models for the development of potent antifungal peptides.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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