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Title 

Structure-antifungal activity relationships of cecropin A hybrid peptides against Trichoderma sp.

Authors 

Song Yub ShinDong Gun LeeSung Gu LeeKil Lyong KimMyung Kyu LeeKyung Soo Hahm

Publisher 

Microbiological Society of Korea

Issue Date 

1997

Citation 

Journal of Microbiology, vol. 35, no. 1, pp. 21-24

Keywords 

Antifungal activityCecropin A hybrid peptideHemolytic activityTrichoderma sp.

Abstract 

The hybrid peptides, CA-ME, CA-MA and CA-BO, with the N-terminal sequence 1-8 of cecropin A and the N-terminal sequences 1-12 of melittin, magainin 2 and bombinin, respectively, have more improved antibacterial activities. CA-MA was found to have stronger antifungal activity against Trichoderma sp than other hybrid peptides and their parental peptides. In order to elucidate the relationships between the peptide structure and antifungal activity, several analogues of CA-MA or CA-BO were also designed and synthesized by the solid phase method. Antifungal activity was measured against T. reesei and T. viride, and hemolytic activity was measured by a solution method against human red blood cells. The residue 16 of CA-MA, Ser, was found to be important for antifungal activity. When the residue was substituted with Leu, antifungal activity was dramatically decreased. CA-MA, P1, P4 and P5 designed in this study showed powerful antifungal activity against T. reesei and T. viride with low hemolytic activity against human red blood cells. These hybrid peptides will be potentially useful model to further design peptides with powerful antifungal activity for the effective therapy of fungal infection and understand the mechanisms of antifungal actions of hybrid peptides.

ISSN 

1225-8873

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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