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Title 

Immunosuppressive characteristics of oligomycin derivatives produced by Streptomyces lydicus MCY-524

Authors 

Sang Yong LeeSang Bae HanHang Sub KimYoung Ho KimHwan Mook KimChang Jin KimSoon-Duk HongJung Joon Lee

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

1997

Citation 

Journal of Microbiology and Biotechnology, vol. 7, no. 1, pp. 56-61

Keywords 

Homooligomycin EImmunosuppressant activitiesStreptomyces lydicus

Abstract 

A strain producing immunosuppressive substances was isolated from a soil in Cheju island. By morphological, cultural, and physiological studies, the strain was identified as Streptomyces lydicus MCY-524. Cultured broth was purified by silica gel, sephadex LH-20 and preparative HPLC and gave two immunosuppressive compounds, MCH-22 and MCH-32. They dramatically suppressed the B cell activation with lipopolysaccharide, T cell activation by mixed lymphocyte response, and primary T-dependent antibody response at a final concentration of 1 μg/ml. They also markedly suppressed the proliferation of lymphocytes induced by lipopolysaccharide, pokeweed mitogen, and concanavaline A at the same concentration. Their suppressive activities, which were comparable to those of cyclosporin A, suggested that they were potent and broad immunotoxic agents on the immune functions of murine lymphocytes.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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