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Title 

Immunosupressive activity of elaiophylins

Authors 

Sang Yong LeeHang Sub KimYoung Ho KimSang Bae HanHwan Mook KimSoon-Duck HongJung Joon Lee

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

1997

Citation 

Journal of Microbiology and Biotechnology, vol. 7, no. 4, pp. 272-277

Keywords 

ElaiophylinImmunosupressiveStreptomyces hygroscopicus MCY846

Abstract 

In the purification of elaiophylin from a culture of Streptomyces hygroscopicus MCY-846, mono- and dimethyl-elaiophylin were obtained through a O-methylation of the hemiketal hydroxy group of elaiophylin. All the three elaiophylins showed cytotoxicity against several human tumor cell lines and murine cell lines. Elaiophylin and monomethyl-elaiophylin also showed antimicrobial activities against gram-positive bacteria and potent inhibitory effects on the activation of B cells by lipopolysaccharide as well as on the proliferation of mouse splenic lymphocytes stimulated by mitogens but dimethyl-elaiophylin did not. This result indicats that elaiophylin and monomethyl-elaiophylin would be strong immunosuppressants. Furthermore this result revealed an interesting structure-activity relationship suggesting that the lack of symmetry and /or the free OH group at C-11 of elaiophylin might be important in conferring biological activities.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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