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Title 

Apoptosis-mediated immunotoxicity of polychlorinated biphenyls (PCBs) in murine splenocytes

Authors 

Byung Sun YooKyu Hoi JungSang Bae HanHwan Mook Kim

Publisher 

Elsevier

Issue Date 

1997

Citation 

Toxicology Letters, vol. 91, no. 0, pp. 83-89

Keywords 

Polychlorinated biphenylsSplenocytesApoptosisImmunotoxicity

Abstract 

Polychlorinated biphenyls (PCBs) exhibited immunotoxicity on antibody forming response to T-dependent antigen of sheep red blood cells, primary activation of T cells by mixed lymphocyte response, and lymphocyte proliferation induced by various mitogens. These immunosuppressions were related with the loss of lymphocyte viability which was determined by the propidium iodide method, and this death was proven to be linked with apoptosis which showed DNA fragmentation detected by the diphenylamine method and agarose gel electrophoresis. The degree of DNA fragmentation was increased in a dose- and time-dependent manner in PCB-treated splenocytes. In conclusion, it was assumed that apoptosis was attributable to the immunotoxicity of PCBs in murine splenocytes.

ISSN 

0378-4274

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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