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Title 

Cloning of the human cDNA sequence encoding the NADH : ubiquinone oxidoreductase MLRQ subunit

Authors 

Jae Wha KimYong Hee LeeHo Bum KangYoung Kyung ChoeTae Wha ChungSung Yeoul ChangKwang Soo LeeIn Seong Choe

Publisher 

International Union of Biochemistry and Molecular Biology

Issue Date 

1997

Citation 

Biochemistry and Molecular Biology International, vol. 43, no. 3, pp. 669-675

Keywords 

NADH:ubiquinone oxidoreductaseMitochondrial respiratory chainMLRQ subunitcDNA sequenceTissue distribution(Human)

Abstract 

A cDNA clone encoding human NADH:ubiquinone oxidoreductase (complex I of mitochondrial respiratory chain) MLRQ subunit was isolated from human fetal liver cDNA library. The clone contained an open reading frame of 246 bp which predicted a protein comprising 81 amino acids with a calculated molecular weight of 9370 Da. The deduced amino acid sequence exhibited 95% homology (88% identity and 7% favored substitution) to that of bovine MLRQ subunit. Northern analysis revealed that the cDNA clone hybridized with a 0.7 kb mRNA species which was present in all tissues examined. The expression level of the 0.7 kb mRNA in heart, skeletal muscle, and brain was higher than in other organs. Human MLRQ cDNA could cross-hybridize with the genomic DNAs from various species.

ISSN 

1039-9712

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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