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Title 

Production of a Ras farnesyl protein transferase inhibitor from Bacillus licheniformis using Plackett-Burman design

Authors 

Kwang Hee SonYong Guk KwonKyung Sook BaeYoung Kook KimByoung-Mog KwonSung Uk KimSong Hae Bok

Publisher 

Springer Verlag (Germany)

Issue Date 

1998

Citation 

Biotechnology Letters, vol. 20, no. 2, pp. 149-151

Keywords 

enzyme inhibitorpotassium dihydrogen phosphateprotein farnesyltransferasearticlebacillus licheniformisbacterial metabolismbioreactor

Abstract 

Compound CBR004 which inhibits Ras farnesyl protein transferase, was produced by Bacillus licheniformis KCTC0372BP. Potassium phosphate and Tryptone were selected as media components for the production of CBR004 among 6 culture-variables using Plackett-Burman design. The yield of CBR004 was 0.99 g/l in a stirred fermenter at the C/N ratio of 1.87.

ISSN 

0141-5492

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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