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Title 

9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic produced by Micromonospora sp. SA246

Authors 

Woon Hyung YeoBong Sik YunNam In BackYoung Ho KimSang Seock KimEun Kyung ParkKyung Sook WhangSeung Hun Yu

Publisher 

Nature Publishing Group

Issue Date 

1997

Citation 

Journal of Antibiotics, vol. 50, no. 7, pp. 546-550

Keywords 

9 hydroxycrisamicin aantineoplastic antibioticcytotoxic agentunclassified drugantibiotic biosynthesisantimicrobial activitycancer cell culturecarbon nuclear magnetic resonancecentral nervous system tumorcolon cancer

Abstract 

9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic, was isolated from a soil microorganism SA246 which was identified as Micromonospora sp. The molecular formula of 9-hydroxycrisamicin A was determined as C32H22O13 based on the HRFAB-MS analysis, and the structure was determined by various NMR experiments. 9-Hydroxycrisamicin A showed weak antimicrobial activity against Gram-positive bacteria acid strong cytotoxic activity against some human cancer cell lines such as SK-OV-3 (ovarian), HCT15 (colon), SK-MEL-2 (melanoma), A549 (lung), XF498 (central nervous system) with ED50 of 0.47 ~ 0.65 μg/ml.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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