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Title 

Expression of human interleukin-2 from native and synthetic genes in E. coli : no correlation between major codon bias and high level expression

Authors 

Hee Won LeeJae Hoon JooSeong Man KangIn Sung SongJong Bum KwonMoon Hi HanDoe Sun Na

Publisher 

Springer Verlag (Germany)

Issue Date 

1992

Citation 

Biotechnology Letters, vol. 14, no. 8, pp. 653-658

Keywords 

complementary dnainterleukin 2synthetic dnaarticlecloning vectorcodonescherichia coligene expressiongenetic engineeringnonhuman

Abstract 

Expression of human IL-2 from the cDNA and synthetic gene was compared using the E. coli expression system. Expression plasmids containing the cDNA or synthetic gene in which the only difference was the coding sequences were constructed. Expression of IL-2 from the cDNA and synthetic gene were estimated to be as right at 18% and 14%, respectively. No correlation was found between the major codon bias and high level expression of IL-2 in this system.

ISSN 

0141-5492

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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