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Title 

T-cell specific immunosuppression by prodigiosin isolated from Serratia marcescens

Authors 

Sang Bae HanHwan Mook KimYoung Hee KimChang Woo LeeEun Sook SonKwang Hee SonSung Uk KimYoung Kook Kim

Publisher 

Elsevier

Issue Date 

1998

Citation 

International Journal of Immunopharmacology, vol. 20, no. 1, pp. 1-13

Keywords 

ProdigiosinImmunosuppressantT-cell mediated immune functionsB-cell mediated immune functionstacrolimusanimal experimentcellular immunitycontrolled studydrug effect

Abstract 

Prodigiosin was isolated from the culture broth of Serratia marcescens B-1231. This compound inhibited the T-cell mediated immune responses such as concanavalin-A induced proliferation, mixed lymphocyte response, local graft vs host reaction and T-dependent antibody response at non-toxic concentrations. However, prodigiosin did not affect B-cell mediated immune functions such as lipopolysaccharide-induced proliferation and -activated polyclonal antibody production at the same concentrations. Prodigiosin did not cause death in vitro to lymphocytes at effective concentrations (< 100 nM) and also did not show toxicity in vivo to lymphoid organs at effective dosages (10 and 30 mg/kg). The pharmacological potencies were comparable to the activities of other T-cell specific immunosuppressants such as cyclosporin A and FK-506. In conclusion, it might be suggested that prodigiosin could be used as an immunosuppressant in clinical and immunological studies.

ISSN 

0192-0561

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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