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Title 

Inhibition of phospholipase C activity by auriculatin and 8-prenylluteone isolated from Erythrina senegalensis

Authors 

Won Keun OhHyun Sun LeeBo Yeon KimHye Kyung ChangYong Hae KimJean WandjiJ Tanyl MbaforTanee FomumJong Seog Ahn

Publisher 

Wiley-Blackwell

Issue Date 

1998

Citation 

Phytotherapy Research, vol. 12, no. 1, pp. 9-12

Keywords 

phospholipase Ctotal inositol phosphatesauriculatin8-prenylluteoneErythrina senegalensisLeguminosae

Abstract 

Auriculatin and 8-prenylluteone were isolated from Erythrina senegalensis (Leguminosae) as inhibitors of phospholipase C (PLC) and phosphoinositides (PI)-turnover in PLC-γ1 overexpressing NIH3T3 fibroblasts (NIH3T3γ1). Auriculatin (1) and 8-prenylluteone (2) showed inhibitory activity with an IC50 value of 20 μM on PLC in vitro as well as the formation of inositol phosphates in platelet-derived growth factor (PDGF)-stimulated NIH3T3γ1 cells. They also showed a moderate cytotoxicity against several human tumour cell lines with an IC50 of 9.0-20 μm, i.e. PC-3 (prostate), NCI-H226 (lung), CRL1579 (melanoma) in vitro.

ISSN 

0951-418X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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