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Title 

Inhibition of angiotensin II receptor binding by quinolone alkaloids from Evodia rutaecarpa

Authors 

Hyun Sun LeeWon Keun OhHee Cheol ChoiJun Won LeeDae Ook KangChan Sun ParkTae Ick MheenJong Seog Ahn

Publisher 

Wiley-Blackwell

Issue Date 

1998

Citation 

Phytotherapy Research, vol. 12, no. 3, pp. 212-214

Keywords 

angiotensin II receptor bindingquinolone alkaloidEvodia rutaecarpaRutaceae

Abstract 

A biologically monitored fractionation of methanol extracts of the fruit of Evodia rutaecarpa led to the isolation of quinolone alkaloids, evocarpin (1), 1-methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (2) and 1- methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (3) as blockers of angiotensin II receptor binding with IC50 values of 43.4 μM, 34. μM and 48.2 μM, respectively.

ISSN 

0951-418X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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