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Title 

Actinomycin D,C₂ and VII, inhibitors of Grb2-Shc interaction produced by Streptomyces

Authors 

Ji Youn NamH K KimKwang Hee SonSung Uk KimByoung-Mog KwonMi Young HanY J ChungSong Hae Bok

Publisher 

Elsevier

Issue Date 

1998

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 8, no. 15, pp. 2001-2001

Keywords 

protein protein interactionstreptomycesStreptomycesGRB2 Adaptor Protein

Abstract 

Actinomycin D, C2 and VII, cyclic peptides, inhibited Grb2 SH2 domain association (IC50 5-7 μM) with a phosphotyrosine containing peptide derived from the Shc protein (pTyr317). Actinomycins are the first examples of nonphosphorylated natural ligands of SH2 domain.

ISSN 

0960-894X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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