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Title 

Synthetic peptides of human papillomavirus type 18 E6 harboring HLA-A2.1 motif can induce peptide-specific cytotoxic T-cells from peripheral blood mononuclear cells of healthy donors

Authors 

Hee Sik YoonMi Kyung ChungSung Shik MinHee Gu LeeWang Don YooKeun Taek ChungNoh Pal JungSue Nie Park

Publisher 

Elsevier

Issue Date 

1998

Citation 

Virus Research, vol. 54, no. 0, pp. 23-29

Keywords 

Human papillomavirus type 18E6 oncoproteinHuman leukocyte antigen-A2.1Epitope peptideCytotoxic T-lymphocytes

Abstract 

To identify cytotoxic T-cell (CTL) epitopes against human papillomavirus type 18 (HPV 18) E6 protein that might be useful for developing peptide-based vaccine against HPV 18 infection, 18 peptides which possibly contain CTL epitopes were selected on the basis of previously described human leukocyte antigen (HLA)-A2.1-binding motif and chemically synthesized. In the binding assay of the synthetic peptides, 8 out of 18 synthetic peptides enhanced the expression of HLA-A2.1 molecules on T2 cell surface, which implies that these peptides were able to bind the HLA molecules. Those peptides having good binding affinity to HLA-A2.1 were tested for their ability to activate CTLs which were isolated from peripheral blood mononuclear cells (PBMCs) of healthy blood donors and to kill the target T2 cells pulsed with the same peptide. Five out of eight tested peptides activated CTLs and killed the target cells.

ISSN 

0168-1702

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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