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Title 

Penicellide, a nonpeptide calpain inhibitor, produced by Penicillium sp. F60760

Authors 

Myung Chul ChungHo Jae LeeHyo Kon ChunYung Hee Kho

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

1998

Citation 

Journal of Microbiology and Biotechnology, vol. 8, no. 2, pp. 188-190

Keywords 

Calpainnonpeptide inhibitorpenicillidePenicillium

Abstract 

Penicillide, having a 5H,7H-dibenzo[b,g][1,5] dioxocin-5-one skeleton, was isolated from the culture broth of Penicillium sp. F60760 as a nonpeptide inhibitor of calpain, a calcium-activated papain-like protease. The IC50 value for the effect of penicillide against m-calpaln was 7.1 μM. However, penicillide did not inhibit papain at a concentration of 200 μM. These results suggest that penicillide is a new class of nonpeptide calpain inhibitor having an eight membered lactone ring.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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