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Title 

Multidrug-resistance reversing activity of medicinal plants

 

약용 식물의 암세포 다제내성 조절 활성 검색

Authors 

Se Eun KimBang yeon hwangYoung Ho KimYoung Jung KimKyung Soon LeeJung Joon Lee

Publisher 

Korean Society of Pharmacognosy

Issue Date 

1997

Citation 

Korean Journal of Pharmacognosy, vol. 28, no. 4, pp. 174-178

Keywords 

multidrug-resistance (MDR)vinblastineCynanchum wilfordiiTorilis japonicaCelastrus orbiculatusMelia toosendanTerminalia chebula

Abstract 

Methanol extracts from 450 plants were screened for multidrug-resistance reversing activity using drug sensitive KB-3-1 and multidrug-resistance KB- V1 cells. Among them, the extracts of Cynanchum wilfordii. Torilis japonica. Celastrus orbiculatus. Melia toosendan and Terminalia chebula strongly potentiated vinblastine cytotoxicity in KB-V1 cells. But their cytotoxicities to both sensitive KB-3-1 and resistant KB-V1 cells were in the same order of magnitude. These results indicate that the above samples would contain the active principles which do not exert their activity solely by cytotoxicity.

ISSN 

0253-3073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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