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Title 

Production of 1-deoxynojirimycin by Streptomyces sp. SID 9135

Authors 

Nam Soo PaekDae Jung KangYong Jin ChoiJung Joon LeeTae Han KimKee Won Kim

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

1997

Citation 

Journal of Microbiology and Biotechnology, vol. 7, no. 4, pp. 262-266

Keywords 

α-glucosidase inhibitor1-deoxynojirimycinStreptomyces sp. SID9135

Abstract 

To increase the high production of 1-deoxynojirimycin (DNJ) from Streptomyces sp. SID9135, the effect of various carbon sources, nitrogen sources, cationic metal ions, the initial pH of the medium, and agitation speed were investigated. The most effective carbon and nitrogen sources were found to be lactose 2.5% (w/v) and soybean meal 2.0% (w/v), respectively. None of the cationic metal ions examined had any detectable stimulating effect on DNJ production except Fe+2 ion. The initial optimum pH for DNJ production ranged from 6-8 and agitation speed was most effective at 400 rpm. In the jar fermentor experiments under optimal culture conditions, the accumulation of DNJ reached about 640 μg/ml after 5 days of cultivation and the level remained the same for a further two days.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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