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Title 

Mode of action of torilin in multidrug-resistant cancer cell lines

Authors 

Se Eun KimYoung Soo HongYoung Choog KimJung Joon Lee

Publisher 

Georg Thieme Verlag

Issue Date 

1998

Citation 

Planta Medica, vol. 64, no. 0, pp. 335-338

Keywords 

TorilinTorilis japonicaUmbelliferaemultidrug-resistance (MDR)drug accumulation and effluxmembrane ATPasedrug transport

Abstract 

The mechanism of action of multidrug-resistance reversing activity of torilin was studied. In vitro experiments for the accumulation and efflux of vinblastine clearly indicated that MDR reversing effect of torilin would directly be associated with the increase of the intracellular accumulation of anticancer drugs by blocking the drug efflux. Furthermore, torilin increased the membrane ATPase activity from KB-V1 cells, suggesting that torilin might function by inhibiting drug transport mediated by P-glycoprotein.

ISSN 

0032-0943

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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