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Title 

A new sesquiterpene ester from Celastrus orbiculatus reversing multidrug resistance in cancer cells

Authors 

Se Eun KimYoung Ho KimJung Joon Lee

Publisher 

American Chemical Society

Issue Date 

1998

Citation 

Journal of Natural Products, vol. 61, no. 0, pp. 108-111

Keywords 

1beta 2beta diacetoxy 6alpha 9alpha bis(benzoyloxy)dihydro beta agarofuranpaclitaxelsesquiterpene esterunclassified drugvinblastinecancer chemotherapycelastrus orbiculatusdrug mechanismhumanhuman cell

Abstract 

In a search for revertants of multidrug-resistance in cancer cells, a novel (1) and two known (2, 3) sesquiterpene esters were isolated from the root of Celastrus orbiculatus. The structure of 1 was elucidated as 1β,2β- diacetoxy-6α,9α-bis(benzoyloxy)dihydro-β-agarofuran. Compounds 1-3 partially or completely reversed resistance to adriamycin, vinblastine, and paclitaxel of multidrug-resistant KB-V1 and MCF7/ADR cells.

ISSN 

0163-3864

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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