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Title | A new sesquiterpene ester from Celastrus orbiculatus reversing multidrug resistance in cancer cells |
Authors | Se Eun Kim; Young Ho Kim; Jung Joon Lee |
Publisher | American Chemical Society |
Issue Date | 1998 |
Citation | Journal of Natural Products, vol. 61, no. 0, pp. 108-111 |
Keywords | 1beta 2beta diacetoxy 6alpha 9alpha bis(benzoyloxy)dihydro beta agarofuran; paclitaxel; sesquiterpene ester; unclassified drug; vinblastine; cancer chemotherapy; celastrus orbiculatus; drug mechanism; human; human cell |
Abstract | In a search for revertants of multidrug-resistance in cancer cells, a novel (1) and two known (2, 3) sesquiterpene esters were isolated from the root of Celastrus orbiculatus. The structure of 1 was elucidated as 1β,2β- diacetoxy-6α,9α-bis(benzoyloxy)dihydro-β-agarofuran. Compounds 1-3 partially or completely reversed resistance to adriamycin, vinblastine, and paclitaxel of multidrug-resistant KB-V1 and MCF7/ADR cells. |
ISSN | 0163-3864 |
Appears in Collections | |
Registered Date |
2017-04-19 |
