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Title 

Effect of α-glycosidase inhibitor in multidrug resistant cell lines

Authors 

Nam Soo PaekJun NamgungJung Joon LeeYoung Jin ChoiTae Han KimKee Won Kim

Publisher 

Springer Verlag (Germany)

Issue Date 

1998

Citation 

Journal of Biochemistry and Molecular Biology, vol. 31, no. 3, pp. 269-273

Keywords 

α-Glucosidase inhibitorsMultidrug resistanceP-glycoprotein

Abstract 

The objective of this study was to evaluate the reversal of multidrug resistance of human cell lines by specific inhibitors of α-glucosidases and mannosidases that had been reported to be involved in N-linked oligosaccharide processing of glycoproteins. N-methyldeoxynojirimycin, 1-deoxynojirimycin, and castanosperminc, which were known to be potent inhibitors of both α-glucosidase I and II, showed no activity against the multidrug resistant phenotype of the cell lines of SNU1DOX, KB-V1, and MCF-7/ADR. In contrast, 1-deoxymannojirimycin, an inhibitor of mannosidase I, resulted in a slight reversal for the vinblastine resistance of the KB-V1 cell line, but did not show any activity toward the other cell lines. Parallel experiments with tunicamycin, an inhibitor of N-linked glycosylation, also resulted in no significant changes in multidrug resistant (MDR) phenotype of the cell lines tested in this work. These observations suggest that the unglycosylation of P-glycoprotein associated with the inhibitor treatments might not be correlated with the reversal of multidrug resistance of the cell lines tested in this study.

ISSN 

1225-8687

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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